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Meeting ID: 926 2343 4275
Passcode: 083075
Biomedical microelectromechanical systems (bioMEMS) enable translational engineering solutions for next-generation diagnosis and therapies to address vital unmet medical needs. In particular, the Microtechnology (µTech) Laboratory at Michigan State University is interested in developing innovative bionic devices based on multiple modalities (e.g. electrical, optical, and chemical) using bioMEMS technologies. These devices form seamless interfaces with biological tissues for potential applications in fundamental neuroscience research, biomedical diagnostics, and therapeutics.
This talk will focus on our recent efforts towards developing hybrid opto-electro-chemo implants at the microscale combining novel inorganic materials with polymeric materials. I will first highlight the development of a wireless opto-μECoG array consists of epidural LEDs and transparent microelectrodes for stimulating and recording neural activity from superficial layers of the cortex. In the second example, an ultra-flexible, highly conductive and transparent microscale electrocorticogram (μECoG) electrode arrays made of PEDOT:PSS-ITO-Ag-ITO assembly are developed for neural recordings in conjunction with optogenetics neuromodulation and imaging. The last example is boron-doped polycrystalline diamond microfiber electrodes for neurotransmitter sensing. The efficacy of the above devices has been demonstrated in-vitro or in-vivo in rat models.
